FZR1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fizzy and cell division cycle 20 related 1 | MIM:603619 | Ensembl:ENSG00000105325 | HGNC:HGNC:24824 | PA134896003 | 19p13.3 |
GO terms in FZR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005680 | anaphase-promoting complex |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IEA | GO:0040020 | regulation of meiotic nuclear division |
| BP | IGI | GO:0045732 | positive regulation of protein catabolic process |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0070306 | lens fiber cell differentiation |
| BP | TAS | GO:0070979 | protein K11-linked ubiquitination |
| BP | IDA | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint |
| BP | IEA | GO:0090344 | negative regulation of cell aging |
| BP | IDA | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0010997 | anaphase-promoting complex binding |
| MF | IEA | GO:0097027 | ubiquitin-protein transferase activator activity |
Gene expression in normal tissue: FZR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FZR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C |
| reactome | R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176417 | Phosphorylation of Emi1 |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | plk1_pathway | PLK1 signaling events |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD12 | Bicalutamide | 4 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD198 | AC1LE7KD | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD369 | TGX-115 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FZR1
CLASSFICATION
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