KLRF1

Summary: KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namekiller cell lectin like receptor F1
OMIM IDMIM:605029
Ensembl IDEnsembl:ENSG00000150045
HGNC IDHGNC:HGNC:13342
PHARMGKB IDPA30169
Map Location12p13.31

GO terms in KLRF1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007166 cell surface receptor signaling pathway
BP TAS GO:0050776 regulation of immune response
CC TAS GO:0005886 plasma membrane
CC TAS GO:0005887 integral component of plasma membrane
CC TAS GO:0016020 membrane
MF TAS GO:0004888 transmembrane signaling receptor activity
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Gene expression in normal tissue: KLRF1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in KLRF1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLRF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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