KLRF1
Summary: KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| killer cell lectin like receptor F1 | MIM:605029 | Ensembl:ENSG00000150045 | HGNC:HGNC:13342 | PA30169 | 12p13.31 |
GO terms in KLRF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0050776 | regulation of immune response |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0030246 | carbohydrate binding |
| MF | TAS | GO:0032393 | MHC class I receptor activity |
Gene expression in normal tissue: KLRF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLRF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLRF1
CLASSFICATION
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