PDE1A
Summary: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:171890 Ensembl IDEnsembl:ENSG00000115252 HGNC IDHGNC:HGNC:8774 PHARMGKB IDPA33122 Map Location2q32.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PDE1A
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity |
MF | TAS | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity |
MF | IEA | GO:0005516 | calmodulin binding |
MF | IEA | GO:0030553 | cGMP binding |
MF | IEA | GO:0046872 | metal ion binding |
MF | TAS | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
Gene expression in normal tissue: PDE1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDE1A
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PDE1A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |