PDE1A

Summary: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphodiesterase 1A
OMIM IDMIM:171890
Ensembl IDEnsembl:ENSG00000115252
HGNC IDHGNC:HGNC:8774
PHARMGKB IDPA33122
Map Location2q32.1

Gene Categories:

DRUGGABLE GENOME

GO terms in PDE1A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
MF TAS GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
MF IEA GO:0005516 calmodulin binding
MF IEA GO:0030553 cGMP binding
MF IEA GO:0046872 metal ion binding
MF TAS GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
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Gene expression in normal tissue: PDE1A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1Protein stability and degradation1

Pathways in PDE1A


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Database
Pathway ID
Pathway Des.
kegg hsa00230 Purine metabolism - Homo sapiens (human)
kegg hsa04020 Calcium signaling pathway - Homo sapiens (human)
kegg hsa04740 Olfactory transduction - Homo sapiens (human)
kegg hsa04742 Taste transduction - Homo sapiens (human)
kegg hsa04924 Renin secretion - Homo sapiens (human)
kegg hsa05032 Morphine addiction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDE1A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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