PLA1A
Summary: The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607460 Ensembl IDEnsembl:ENSG00000144837 HGNC IDHGNC:HGNC:17661 PHARMGKB IDPA134955851 Map Location3q13.33 | |||||
GO terms in PLA1A
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity |
| MF | TAS | GO:0052739 | phosphatidylserine 1-acylhydrolase activity |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006658 | phosphatidylserine metabolic process |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | TAS | GO:0036150 | phosphatidylserine acyl-chain remodeling |
Gene expression in normal tissue: PLA1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLA1A
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1482801 | Acyl chain remodelling of PS |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLA1A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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