POLK


Summary: This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA polymerase kappaMIM:605650Ensembl:ENSG00000122008HGNC:HGNC:9183PA335035q13.3

Gene Categories:

DNA REPAIR

GO terms in POLK


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003684damaged DNA binding
MFIBAGO:0003887DNA-directed DNA polymerase activity
MFIEAGO:0003887DNA-directed DNA polymerase activity
MFIBAGO:0005515protein binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0016604nuclear body
CCIBAGO:0090734site of DNA damage
CCIDAGO:0090734site of DNA damage
BPIEAGO:0006260DNA replication
BPIBAGO:0006281DNA repair
BPIDAGO:0006281DNA repair
BPTASGO:0006281DNA repair
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPIMPGO:0006297nucleotide-excision repair, DNA gap filling
BPTASGO:0006297nucleotide-excision repair, DNA gap filling
BPIDAGO:0006974cellular response to DNA damage stimulus
BPTASGO:0019985translesion synthesis
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPIDAGO:0034644cellular response to UV
BPIBAGO:0042276error-prone translesion synthesis
BPIDAGO:0042276error-prone translesion synthesis
BPTASGO:0042276error-prone translesion synthesis
BPIBAGO:0070987error-free translesion synthesis

Gene expression in normal tissue: POLK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POLK


DatabasePathway IDPathway Des.
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
reactomeR-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactomeR-HSA-5655862Translesion synthesis by POLK
reactomeR-HSA-5656169Termination of translesion DNA synthesis
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-73893DNA Damage Bypass
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLK

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