PDGFA
Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:173430 Ensembl IDEnsembl:ENSG00000197461 HGNC IDHGNC:HGNC:8799 PHARMGKB IDPA33144 Map Location7p22.3 | |||||
GO terms in PDGFA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IDA | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005518 | collagen binding |
Gene expression in normal tissue: PDGFA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDGFA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | pdgfpathway | pdgf signaling pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDGFA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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