GPRC5B
Summary: This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor class C group 5 member B | MIM:605948 | Ensembl:ENSG00000167191 | HGNC:HGNC:13308 | PA28938 | 16p12.3 |
GO terms in GPRC5B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | ISS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0045666 | positive regulation of neuron differentiation |
| BP | ISS | GO:0050729 | positive regulation of inflammatory response |
| BP | ISS | GO:0060907 | positive regulation of macrophage cytokine production |
| BP | ISS | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | ISS | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| MF | ISS | GO:0001664 | G-protein coupled receptor binding |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | ISS | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0030295 | protein kinase activator activity |
Gene expression in normal tissue: GPRC5B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPRC5B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP501 | GPCRs, Class C Metabotropic glutamate, pheromone |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPRC5B
CLASSFICATION
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