GNG13
Summary: Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein subunit gamma 13 | MIM:607298 | Ensembl:ENSG00000127588 | HGNC:HGNC:14131 | PA28783 | 16p13.3 |
GO terms in GNG13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0031681 | G-protein beta-subunit binding |
| BP | IEA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0050909 | sensory perception of taste |
| CC | IEA | GO:0005834 | heterotrimeric G-protein complex |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030425 | dendrite |
Gene expression in normal tissue: GNG13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GNG13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163359 | Glucagon signaling in metabolic regulation |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-202040 | G-protein activation |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 |
| reactome | R-HSA-392451 | G beta:gamma signalling through PI3Kgamma |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392518 | Signal amplification |
| reactome | R-HSA-392518 | Signal amplification |
| reactome | R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor |
| reactome | R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion |
| reactome | R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion |
| reactome | R-HSA-400508 | Incretin synthesis, secretion, and inactivation |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-418217 | G beta:gamma signalling through PLC beta |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 |
| reactome | R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-420092 | Glucagon-type ligand receptors |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-428930 | Thromboxane signalling through TP receptor |
| reactome | R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins |
| reactome | R-HSA-445717 | Aquaporin-mediated transport |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| reactome | R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) |
| reactome | R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) |
| reactome | R-HSA-500657 | Presynaptic function of Kainate receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GNG13
CLASSFICATION
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