ABCB1
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily B member 1 | MIM:171050 | Ensembl:ENSG00000085563 | HGNC:HGNC:40 | PA267 | 7q21.12 |
GO terms in ABCB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008559 | xenobiotic transmembrane transporting ATPase activity |
| MF | TAS | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | IDA | GO:0090554 | phosphatidylcholine-translocating ATPase activity |
| MF | IDA | GO:0090555 | phosphatidylethanolamine-translocating ATPase activity |
| MF | IDA | GO:0099038 | ceramide-translocating ATPase activity |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0006855 | drug transmembrane transport |
| BP | TAS | GO:0042493 | response to drug |
| BP | IEA | GO:0042908 | xenobiotic transport |
| BP | IDA | GO:0045332 | phospholipid translocation |
| BP | IMP | GO:0047484 | regulation of response to osmotic stress |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IMP | GO:0072089 | stem cell proliferation |
| BP | IDA | GO:0099040 | ceramide translocation |
| BP | IMP | GO:1901529 | positive regulation of anion channel activity |
| BP | IMP | GO:2001225 | regulation of chloride transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ABCB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA145011109 | Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011110 | Pravastatin Pathway, Pharmacokinetics |
| pharmgkb | PA145011113 | Warfarin Pathway, Pharmacokinetics |
| pharmgkb | PA146123006 | Codeine and Morphine Pathway, Pharmacokinetics |
| pharmgkb | PA150981002 | Vinka Alkaloid Pathway, Pharmacokinetics |
| pharmgkb | PA152325160 | Gefitinib Pathway, Pharmacokinetics |
| pharmgkb | PA152530846 | Proton Pump Inhibitor Pathway, Pharmacokinetics |
| pharmgkb | PA154424674 | Clopidogrel Pathway, Pharmacokinetics |
| pharmgkb | PA154426155 | Taxane Pathway, Pharmacokinetics |
| pharmgkb | PA154426903 | Erlotinib Pathway, Pharmacokinetics |
| pharmgkb | PA164713427 | Imatinib Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA164713429 | Citalopram Pathway, Pharmacokinetics |
| pharmgkb | PA165292163 | Doxorubicin Pathway (Cancer Cell), Pharmacodynamics |
| pharmgkb | PA165292177 | Doxorubicin Pathway, Pharmacokinetics |
| pharmgkb | PA165816270 | Methotrexate Pathway (Brain Cell), Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| pharmgkb | PA165859361 | Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165964832 | Mycophenolic acid Pathway, Pharmacokinetics |
| pharmgkb | PA165986114 | Tacrolimus/Cyclosporine Pathway, Pharmacokinetics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA2001 | Irinotecan Pathway, Pharmacokinetics |
| pharmgkb | PA2025 | Etoposide Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2029 | Irinotecan Pathway, Pharmacodynamics |
| pharmgkb | PA2031 | Statin Pathway, Pharmacodynamics |
| smpdb | SMP00260 | Clopidogrel Action Pathway |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00434 | Paclitaxel Action Pathway |
| smpdb | SMP00435 | Docetaxel Action Pathway |
| smpdb | SMP00436 | Vinblastine Action Pathway |
| smpdb | SMP00437 | Vincristine Action Pathway |
| smpdb | SMP00438 | Vindesine Action Pathway |
| smpdb | SMP00439 | Vinorelbine Action Pathway |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00472 | Erlotinib Action Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00610 | Clopidogrel Metabolism Pathway |
| smpdb | SMP00636 | Venlafaxine Metabolism Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| smpdb | SMP00650 | Doxorubicin Metabolism Pathway |
| smpdb | SMP00652 | Mycophenolic Acid Metabolism Pathway |
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP3672 | LncRNA-mediated mechanisms of therapeutic resistance |
| wikipathways | WP4010 | Liver steatosis AOP |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2161517 | Abacavir transmembrane transport |
| reactome | R-HSA-2161522 | Abacavir transport and metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| biocarta | mrppathway | multi-drug resistance factors |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD288 | Carboplatin | 1 |
| iGMDRD328 | AR-42 | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD68 | Paclitaxel | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCB1
CLASSFICATION
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