SLC25A3
Summary: The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600370 Ensembl IDEnsembl:ENSG00000075415 HGNC IDHGNC:HGNC:10989 PHARMGKB IDPA35865 Map Location12q23.1 | |||||
GO terms in SLC25A3
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005315 | inorganic phosphate transmembrane transporter activity |
| MF | TAS | GO:0015317 | phosphate:proton symporter activity |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| BP | IBA | GO:0035435 | phosphate ion transmembrane transport |
| BP | IEA | GO:1902600 | proton transmembrane transport |
| CC | IDA | GO:0005739 | mitochondrion |
Gene expression in normal tissue: SLC25A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC25A3
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cmyb_pathway | C-MYB transcription factor network |
Showing 1 to 1 of 1 rows
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC25A3
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.