PLA2G4A
Summary: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600522 Ensembl IDEnsembl:ENSG00000116711 HGNC IDHGNC:HGNC:9035 PHARMGKB IDPA271 Map Location1q31.1 | |||||
GO terms in PLA2G4A
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004622 | lysophospholipase activity |
| MF | IBA | GO:0004623 | phospholipase A2 activity |
| MF | IDA | GO:0004623 | phospholipase A2 activity |
| MF | NAS | GO:0004623 | phospholipase A2 activity |
| MF | TAS | GO:0004623 | phospholipase A2 activity |
| MF | IBA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: PLA2G4A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLA2G4A
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165947317 | Leukotriene modifiers pathway, Pharmacodynamics |
| pid | endothelinpathway | Endothelins |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLA2G4A
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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