PLA2G4A
Summary: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase A2 group IVA | MIM:600522 | Ensembl:ENSG00000116711 | HGNC:HGNC:9035 | PA271 | 1q31.1 |
GO terms in PLA2G4A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004622 | lysophospholipase activity |
| MF | IBA | GO:0004623 | phospholipase A2 activity |
| MF | IDA | GO:0004623 | phospholipase A2 activity |
| MF | NAS | GO:0004623 | phospholipase A2 activity |
| MF | TAS | GO:0004623 | phospholipase A2 activity |
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IBA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | IDA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | TAS | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity |
| MF | EXP | GO:0047498 | calcium-dependent phospholipase A2 activity |
| MF | IBA | GO:0047498 | calcium-dependent phospholipase A2 activity |
| MF | IEA | GO:0102567 | phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| MF | IEA | GO:0102568 | phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
| BP | TAS | GO:0006644 | phospholipid metabolic process |
| BP | TAS | GO:0006654 | phosphatidic acid biosynthetic process |
| BP | NAS | GO:0006663 | platelet activating factor biosynthetic process |
| BP | NAS | GO:0006690 | icosanoid metabolic process |
| BP | IEA | GO:0009395 | phospholipid catabolic process |
| BP | TAS | GO:0019369 | arachidonic acid metabolic process |
| BP | TAS | GO:0035965 | cardiolipin acyl-chain remodeling |
| BP | TAS | GO:0036148 | phosphatidylglycerol acyl-chain remodeling |
| BP | TAS | GO:0036149 | phosphatidylinositol acyl-chain remodeling |
| BP | TAS | GO:0036150 | phosphatidylserine acyl-chain remodeling |
| BP | TAS | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| BP | TAS | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0046456 | icosanoid biosynthetic process |
| BP | IBA | GO:0046475 | glycerophospholipid catabolic process |
| BP | IEA | GO:0050482 | arachidonic acid secretion |
| BP | IEA | GO:0071236 | cellular response to antibiotic |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005811 | lipid droplet |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | NAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
Gene expression in normal tissue: PLA2G4A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLA2G4A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165947317 | Leukotriene modifiers pathway, Pharmacodynamics |
| pid | endothelinpathway | Endothelins |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP2526 | PDGF Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| humancyc | LIPASYN-PWY | phospholipases |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| kegg | hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| kegg | hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| kegg | hsa00592 | alpha-Linolenic acid metabolism - Homo sapiens (human) |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_RAGE | RAGE |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111995 | phospho-PLA2 pathway |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1482788 | Acyl chain remodelling of PC |
| reactome | R-HSA-1482798 | Acyl chain remodeling of CL |
| reactome | R-HSA-1482801 | Acyl chain remodelling of PS |
| reactome | R-HSA-1482839 | Acyl chain remodelling of PE |
| reactome | R-HSA-1482922 | Acyl chain remodelling of PI |
| reactome | R-HSA-1482925 | Acyl chain remodelling of PG |
| reactome | R-HSA-1483115 | Hydrolysis of LPC |
| reactome | R-HSA-1483166 | Synthesis of PA |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392518 | Signal amplification |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-432142 | Platelet sensitization by LDL |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| biocarta | sppapathway | aspirin blocks signaling pathway involved in platelet activation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLA2G4A
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.