Summary: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].

plasminogen activator, urokinaseMIM:191840Ensembl:ENSG00000122861HGNC:HGNC:9052PA3338210q22.2

GO terms in PLAU

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001666response to hypoxia
BPTASGO:0007165signal transduction
BPIEAGO:0007596blood coagulation
BPIDAGO:0010469regulation of signaling receptor activity
BPIEAGO:0014909smooth muscle cell migration
BPIDAGO:0014910regulation of smooth muscle cell migration
BPIDAGO:0030335positive regulation of cell migration
BPIBAGO:0031639plasminogen activation
BPIDAGO:0031639plasminogen activation
BPIBAGO:0033628regulation of cell adhesion mediated by integrin
BPIDAGO:0033628regulation of cell adhesion mediated by integrin
BPIEAGO:0042127regulation of cell proliferation
BPTASGO:0043312neutrophil degranulation
BPICGO:0061041regulation of wound healing
BPIDAGO:2000097regulation of smooth muscle cell-matrix adhesion
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCTASGO:0035579specific granule membrane
CCHDAGO:0070062extracellular exosome
CCTASGO:0070821tertiary granule membrane
MFIBAGO:0004252serine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: PLAU

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLAU

DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-75205Dissolution of Fibrin Clot
biocartafibrinolysispathwayfibrinolysis pathway
biocartaplateletapppathwayplatelet amyloid precursor protein pathway
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidap1_pathwayAP-1 transcription factor network
pidatf2_pathwayATF-2 transcription factor network
pidavb3_opn_pathwayOsteopontin-mediated events
pide2f_pathwayE2F transcription factor network
pidfgf_pathwayFGF signaling pathway
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidintegrin5_pathwayBeta5 beta6 beta7 and beta8 integrin cell surface interactions
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP272Blood Clotting Cascade
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3897Dengue-2 Interactions with Blood Clotting Cascade
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP558Complement and Coagulation Cascades
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP710DNA Damage Response (only ATM dependent)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLAU