Summary: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

phospholipase C beta 3MIM:600230Ensembl:ENSG00000149782HGNC:HGNC:9056PA3338611q13.1

GO terms in PLCB3

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004629phospholipase C activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFHDAGO:0045296cadherin binding
CCIDAGO:0032991protein-containing complex
BPIDAGO:0003073regulation of systemic arterial blood pressure
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0016042lipid catabolic process
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0043647inositol phosphate metabolic process

Gene expression in normal tissue: PLCB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLCB3

DatabasePathway IDPathway Des.
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3958GPR40 Pathway
wikipathwaysWP422MAPK Cascade
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA161749006Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidcxcr4_pathwayCXCR4-mediated signaling events
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidlysophospholipid_pathwayLPA receptor mediated events
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
humancycPWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancycPWY-6367D-myo-inositol-5-phosphate metabolism
humancycPWY-6371superpathway of inositol phosphate compounds
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-399997Acetylcholine regulates insulin secretion
reactomeR-HSA-399997Acetylcholine regulates insulin secretion
reactomeR-HSA-400451Free fatty acids regulate insulin secretion
reactomeR-HSA-400451Free fatty acids regulate insulin secretion
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418217G beta:gamma signalling through PLC beta
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
reactomeR-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
reactomeR-HSA-500657Presynaptic function of Kainate receptors

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCB3