PLCB3


Summary: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:600230
PHARMGKB IDPA33386
Map Location11q13.1

GO terms in PLCB3


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004435 phosphatidylinositol phospholipase C activity
MF TAS GO:0004629 phospholipase C activity
MF IEA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IDA GO:0005516 calmodulin binding
MF HDA GO:0045296 cadherin binding
Showing 1 to 6 of 16 rows rows per page

Gene expression in normal tissue: PLCB3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in PLCB3


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2059 Alzheimers Disease
wikipathways WP26 Signal Transduction of S1P Receptor
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP35 G Protein Signaling Pathways
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP3929 Chemokine signaling pathway
Showing 1 to 6 of 114 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCB3

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​