PLS3


Summary: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
plastin 3MIM:300131Ensembl:ENSG00000102024HGNC:HGNC:9091PA33418Xq23

GO terms in PLS3


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0051017actin filament bundle assembly
BPIBAGO:0051639actin filament network formation
BPIMPGO:0060348bone development
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIBAGO:0005884actin filament
CCIDAGO:0005886plasma membrane
CCIBAGO:0032432actin filament bundle
MFIEAGO:0005509calcium ion binding
MFIBAGO:0051015actin filament binding

Gene expression in normal tissue: PLS3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLS3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLS3

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