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PLS3

Summary: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
plastin 3	MIM:300131	Ensembl:ENSG00000102024	HGNC:HGNC:9091	PA33418	Xq23

GO terms in PLS3

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0051017	actin filament bundle assembly
BP	IBA	GO:0051639	actin filament network formation
BP	IMP	GO:0060348	bone development
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	IBA	GO:0005884	actin filament
CC	IDA	GO:0005886	plasma membrane
CC	IBA	GO:0032432	actin filament bundle
MF	IEA	GO:0005509	calcium ion binding
MF	IBA	GO:0051015	actin filament binding

Gene expression in normal tissue: PLS3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLS3

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLS3

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