Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

promyelocytic leukemiaMIM:102578Ensembl:ENSG00000140464HGNC:HGNC:9113PA3343915q24.1

GO terms in PML

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001666response to hypoxia
BPISSGO:0001932regulation of protein phosphorylation
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIMPGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006606protein import into nucleus
BPIEAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPISSGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIBAGO:0007050cell cycle arrest
BPIEAGO:0007050cell cycle arrest
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007182common-partner SMAD protein phosphorylation
BPIMPGO:0008285negative regulation of cell proliferation
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress
BPIEAGO:0009411response to UV
BPIEAGO:0010332response to gamma radiation
BPISSGO:0010522regulation of calcium ion transport into cytosol
BPIEAGO:0010761fibroblast migration
BPIEAGO:0016032viral process
BPIMPGO:0016525negative regulation of angiogenesis
BPIEAGO:0030099myeloid cell differentiation
BPIEAGO:0030155regulation of cell adhesion
BPIDAGO:0030308negative regulation of cell growth
BPIBAGO:0030578PML body organization
BPIMPGO:0030578PML body organization
BPIMPGO:0032206positive regulation of telomere maintenance
BPISSGO:0032469endoplasmic reticulum calcium ion homeostasis
BPISSGO:0032922circadian regulation of gene expression
BPIDAGO:0034097response to cytokine
BPISSGO:0042752regulation of circadian rhythm
BPISSGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPISSGO:0043153entrainment of circadian clock by photoperiod
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIBAGO:0045087innate immune response
BPIDAGO:0045087innate immune response
BPIEAGO:0045165cell fate commitment
BPIEAGO:0045345positive regulation of MHC class I biosynthetic process
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048146positive regulation of fibroblast proliferation
BPIEAGO:0048384retinoic acid receptor signaling pathway
BPIEAGO:0050713negative regulation of interleukin-1 beta secretion
BPIDAGO:0051457maintenance of protein location in nucleus
BPIEAGO:0051607defense response to virus
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPIEAGO:0060444branching involved in mammary gland duct morphogenesis
BPIDAGO:0065003protein-containing complex assembly
BPIEAGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIEAGO:0071353cellular response to interleukin-4
BPIDAGO:0090398cellular senescence
BPIEAGO:0097191extrinsic apoptotic signaling pathway
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIBAGO:1902187negative regulation of viral release from host cell
BPIDAGO:1902187negative regulation of viral release from host cell
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPIMPGO:2000059negative regulation of ubiquitin-dependent protein catabolic process
BPIMPGO:2000779regulation of double-strand break repair
BPIMPGO:2001238positive regulation of extrinsic apoptotic signaling pathway
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0016363nuclear matrix
CCIEAGO:0016363nuclear matrix
CCIBAGO:0016605PML body
CCIDAGO:0016605PML body
CCIDAGO:0016605PML body
CCTASGO:0016605PML body
CCIEAGO:0031901early endosome membrane
CCISSGO:0042406extrinsic component of endoplasmic reticulum membrane
MFIEAGO:0003677DNA binding
MFIBAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0032183SUMO binding
MFIPIGO:0032183SUMO binding
MFIPIGO:0042803protein homodimerization activity
MFIBAGO:0046332SMAD binding
MFIEAGO:0046332SMAD binding

Gene expression in normal tissue: PML

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PML

DatabasePathway IDPathway Des.
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3232142SUMOylation of ubiquitinylation proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804758Regulation of TP53 Activity through Acetylation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8934593Regulation of RUNX1 Expression and Activity
reactomeR-HSA-8948747Regulation of PTEN localization
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-913531Interferon Signaling
biocartapmlpathwayregulation of transcriptional activity by pml
pidmtor_4pathwaymTOR signaling pathway
pidmyc_pathwayC-MYC pathway
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pidtgfbrpathwayTGF-beta receptor signaling
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP707DNA Damage Response

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD162All-trans Retinoic Acid3
iGMDRD679Bistramide A6
iGMDRD286Nsc 6328391

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PML