Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].

FXYD domain containing ion transport regulator 5MIM:606669Ensembl:ENSG00000089327HGNC:HGNC:4029PA2844519q13.12

Gene Categories:


GO terms in FXYD5

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003779actin binding
MFIEAGO:0005216ion channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0017080sodium channel regulator activity
MFIDAGO:0045296cadherin binding
CCIDAGO:0016021integral component of membrane
BPNASGO:0030033microvillus assembly
BPIEAGO:0034220ion transmembrane transport
BPNASGO:0046588negative regulation of calcium-dependent cell-cell adhesion
BPIBAGO:2000649regulation of sodium ion transmembrane transporter activity

Gene expression in normal tissue: FXYD5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FXYD5

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FXYD5