FXYD5
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FXYD domain containing ion transport regulator 5 | MIM:606669 | Ensembl:ENSG00000089327 | HGNC:HGNC:4029 | PA28445 | 19q13.12 |
GO terms in FXYD5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003779 | actin binding |
| MF | IEA | GO:0005216 | ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017080 | sodium channel regulator activity |
| MF | IDA | GO:0045296 | cadherin binding |
| CC | IDA | GO:0016021 | integral component of membrane |
| BP | NAS | GO:0030033 | microvillus assembly |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | NAS | GO:0046588 | negative regulation of calcium-dependent cell-cell adhesion |
| BP | IBA | GO:2000649 | regulation of sodium ion transmembrane transporter activity |
Gene expression in normal tissue: FXYD5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FXYD5
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FXYD5
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