POLA1
Summary: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA polymerase alpha 1, catalytic subunit | MIM:312040 | Ensembl:ENSG00000101868 | HGNC:HGNC:9173 | PA162399856 | Xp22.11-p21.3 |
GO terms in POLA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IMP | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IMP | GO:0006260 | DNA replication |
| BP | IDA | GO:0006269 | DNA replication, synthesis of RNA primer |
| BP | IDA | GO:0006270 | DNA replication initiation |
| BP | IMP | GO:0006271 | DNA strand elongation involved in DNA replication |
| BP | IBA | GO:0006272 | leading strand elongation |
| BP | IDA | GO:0006272 | leading strand elongation |
| BP | IBA | GO:0006273 | lagging strand elongation |
| BP | IDA | GO:0006273 | lagging strand elongation |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IMP | GO:0006281 | DNA repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | IBA | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IMP | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | IDA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | IBA | GO:1902975 | mitotic DNA replication initiation |
| BP | IBA | GO:1902981 | synthesis of RNA primer involved in mitotic DNA replication |
| BP | IMP | GO:1904161 | DNA synthesis involved in UV-damage excision repair |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005658 | alpha DNA polymerase:primase complex |
| CC | IDA | GO:0005658 | alpha DNA polymerase:primase complex |
| CC | TAS | GO:0005658 | alpha DNA polymerase:primase complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016363 | nuclear matrix |
| MF | IDA | GO:0000166 | nucleotide binding |
| MF | IEA | GO:0001882 | nucleoside binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003688 | DNA replication origin binding |
| MF | IDA | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IMP | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017076 | purine nucleotide binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0051539 | 4 iron, 4 sulfur cluster binding |
Gene expression in normal tissue: POLA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174411 | Polymerase switching on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-174430 | Telomere C-strand synthesis initiation |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68952 | DNA replication initiation |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69091 | Polymerase switching |
| reactome | R-HSA-69109 | Leading Strand Synthesis |
| reactome | R-HSA-69166 | Removal of the Flap Intermediate |
| reactome | R-HSA-69183 | Processive synthesis on the lagging strand |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP404 | Nucleotide Metabolism |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLA1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.