POLD1


Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA polymerase delta 1, catalytic subunitMIM:174761Ensembl:ENSG00000062822HGNC:HGNC:9175PA3349619q13.33

GO terms in POLD1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000166nucleotide binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003682chromatin binding
MFIDAGO:0003684damaged DNA binding
MFIBAGO:0003887DNA-directed DNA polymerase activity
MFIMPGO:0003887DNA-directed DNA polymerase activity
MFTASGO:0003887DNA-directed DNA polymerase activity
MFIPIGO:0005515protein binding
MFIBAGO:00082963'-5'-exodeoxyribonuclease activity
MFIEAGO:0046872metal ion binding
MFIEAGO:00515394 iron, 4 sulfur cluster binding
BPTASGO:0000723telomere maintenance
BPIDAGO:0000731DNA synthesis involved in DNA repair
BPIMPGO:0000731DNA synthesis involved in DNA repair
BPIMPGO:0006260DNA replication
BPIBAGO:0006261DNA-dependent DNA replication
BPTASGO:0006281DNA repair
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPIBAGO:0006287base-excision repair, gap-filling
BPIDAGO:0006287base-excision repair, gap-filling
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPIBAGO:0006297nucleotide-excision repair, DNA gap filling
BPICGO:0006297nucleotide-excision repair, DNA gap filling
BPIMPGO:0006297nucleotide-excision repair, DNA gap filling
BPTASGO:0006297nucleotide-excision repair, DNA gap filling
BPTASGO:0009411response to UV
BPTASGO:0019985translesion synthesis
BPTASGO:0032201telomere maintenance via semi-conservative replication
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPIDAGO:0034644cellular response to UV
BPTASGO:0042769DNA damage response, detection of DNA damage
BPIBAGO:0045004DNA replication proofreading
BPIMPGO:0055089fatty acid homeostasis
CCIDAGO:0000109nucleotide-excision repair complex
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCHDAGO:0016020membrane
CCIDAGO:0016235aggresome
CCIBAGO:0043625delta DNA polymerase complex

Gene expression in normal tissue: POLD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in POLD1


DatabasePathway IDPathway Des.
wikipathwaysWP186Homologous recombination
wikipathwaysWP4022Pyrimidine metabolism
wikipathwaysWP404Nucleotide Metabolism
wikipathwaysWP466DNA Replication
wikipathwaysWP531Mismatch repair
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa03030DNA replication - Homo sapiens (human)
kegghsa03410Base excision repair - Homo sapiens (human)
kegghsa03420Nucleotide excision repair - Homo sapiens (human)
kegghsa03430Mismatch repair - Homo sapiens (human)
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
reactomeR-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactomeR-HSA-110314Recognition of DNA damage by PCNA-containing replication complex
reactomeR-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathway
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174411Polymerase switching on the C-strand of the telomere
reactomeR-HSA-174414Processive synthesis on the C-strand of the telomere
reactomeR-HSA-174417Telomere C-strand (Lagging Strand) Synthesis
reactomeR-HSA-174437Removal of the Flap Intermediate from the C-strand
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-2564830Cytosolic iron-sulfur cluster assembly
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
reactomeR-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
reactomeR-HSA-5651801PCNA-Dependent Long Patch Base Excision Repair
reactomeR-HSA-5656169Termination of translesion DNA synthesis
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-69091Polymerase switching
reactomeR-HSA-69109Leading Strand Synthesis
reactomeR-HSA-69166Removal of the Flap Intermediate
reactomeR-HSA-69183Processive synthesis on the lagging strand
reactomeR-HSA-69186Lagging Strand Synthesis
reactomeR-HSA-69190DNA strand elongation
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-73884Base Excision Repair
reactomeR-HSA-73886Chromosome Maintenance
reactomeR-HSA-73893DNA Damage Bypass
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73933Resolution of Abasic Sites (AP sites)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLD1

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