POLD1
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA polymerase delta 1, catalytic subunit | MIM:174761 | Ensembl:ENSG00000062822 | HGNC:HGNC:9175 | PA33496 | 19q13.33 |
GO terms in POLD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IMP | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | TAS | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008296 | 3'-5'-exodeoxyribonuclease activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| BP | TAS | GO:0000723 | telomere maintenance |
| BP | IDA | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IMP | GO:0000731 | DNA synthesis involved in DNA repair |
| BP | IMP | GO:0006260 | DNA replication |
| BP | IBA | GO:0006261 | DNA-dependent DNA replication |
| BP | TAS | GO:0006281 | DNA repair |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | IBA | GO:0006287 | base-excision repair, gap-filling |
| BP | IDA | GO:0006287 | base-excision repair, gap-filling |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | IBA | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | IC | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | IMP | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | TAS | GO:0009411 | response to UV |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | TAS | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | IBA | GO:0045004 | DNA replication proofreading |
| BP | IMP | GO:0055089 | fatty acid homeostasis |
| CC | IDA | GO:0000109 | nucleotide-excision repair complex |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016235 | aggresome |
| CC | IBA | GO:0043625 | delta DNA polymerase complex |
Gene expression in normal tissue: POLD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP186 | Homologous recombination |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP404 | Nucleotide Metabolism |
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP531 | Mismatch repair |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex |
| reactome | R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174411 | Polymerase switching on the C-strand of the telomere |
| reactome | R-HSA-174414 | Processive synthesis on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-174437 | Removal of the Flap Intermediate from the C-strand |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-69091 | Polymerase switching |
| reactome | R-HSA-69109 | Leading Strand Synthesis |
| reactome | R-HSA-69166 | Removal of the Flap Intermediate |
| reactome | R-HSA-69183 | Processive synthesis on the lagging strand |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLD1
CLASSFICATION
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