POLD1
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:174761 Ensembl IDEnsembl:ENSG00000062822 HGNC IDHGNC:HGNC:9175 PHARMGKB IDPA33496 Map Location19q13.33 | |||||
GO terms in POLD1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IMP | GO:0003887 | DNA-directed DNA polymerase activity |
Gene expression in normal tissue: POLD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLD1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP186 | Homologous recombination |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP404 | Nucleotide Metabolism |
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP531 | Mismatch repair |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLD1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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