POLE

Summary: This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameDNA polymerase epsilon, catalytic subunit
OMIM IDMIM:174762
Ensembl IDEnsembl:ENSG00000177084
HGNC IDHGNC:HGNC:9177
PHARMGKB IDPA277
Map Location12q24.33

GO terms in POLE


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000166 nucleotide binding
MF IBA GO:0003677 DNA binding
MF IDA GO:0003677 DNA binding
MF IDA GO:0003682 chromatin binding
MF IBA GO:0003887 DNA-directed DNA polymerase activity
MF IMP GO:0003887 DNA-directed DNA polymerase activity
Showing 1 to 6 of 29 rows rows per page

Gene expression in normal tissue: POLE

Gene-model tissue-cancer distribution: Bubble Plot

BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioma model num: 5BRAINtissue: BRAIN cancer: Glioblastoma Multiforme (GBM) model num: 1UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 5

Gene-drug pathway distribution

undefined3

Pathways in POLE


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactome R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
reactome R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
reactome R-HSA-157579 Telomere Maintenance
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis
Showing 1 to 6 of 47 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD974 PD1 blockade 3
iGMDRD978 Pembrolizumab 2
iGMDRD973 PD1 Ab inhibitor 6
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in POLE

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.