POLR2F
Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604414 Ensembl IDEnsembl:ENSG00000100142 HGNC IDHGNC:HGNC:9193 PHARMGKB IDPA33513 Map Location22q13.1 | |||||
Gene Categories:
DNA REPAIRGO terms in POLR2F
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001054 | RNA polymerase I activity |
| MF | IBA | GO:0001055 | RNA polymerase II activity |
| MF | IBA | GO:0001056 | RNA polymerase III activity |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003899 | DNA-directed 5'-3' RNA polymerase activity |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
Gene expression in normal tissue: POLR2F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLR2F
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03020 | RNA polymerase - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLR2F
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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