SIAE


Summary: This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

DRUGGABLE GENOME

GO terms in SIAE


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0002682 regulation of immune system process
BP IDA GO:0005975 carbohydrate metabolic process
CC HDA GO:0005615 extracellular space
CC IEA GO:0005764 lysosome
CC HDA GO:0070062 extracellular exosome
MF IDA GO:0001681 sialate O-acetylesterase activity
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Gene expression in normal tissue: SIAE

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in SIAE


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIAE

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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