SSH1
Summary: The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606778 Ensembl IDEnsembl:ENSG00000084112 HGNC IDHGNC:HGNC:30579 PHARMGKB IDPA134941788 Map Location12q24.11 | |||||
GO terms in SSH1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000902 | cell morphogenesis |
| BP | IMP | GO:0006470 | protein dephosphorylation |
| BP | IBA | GO:0008064 | regulation of actin polymerization or depolymerization |
| BP | IBA | GO:0010591 | regulation of lamellipodium assembly |
| BP | IMP | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0031915 | positive regulation of synaptic plasticity |
Gene expression in normal tissue: SSH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SSH1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | fgf_pathway | FGF signaling pathway |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SSH1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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