PON2
Summary: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameparaoxonase 2 OMIM IDMIM:602447 Ensembl IDEnsembl:ENSG00000105854 HGNC IDHGNC:HGNC:9205 PHARMGKB IDPA33530 Map Location7q21.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in PON2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004064 | arylesterase activity |
| MF | IBA | GO:0016788 | hydrolase activity, acting on ester bonds |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0102007 | acyl-L-homoserine-lactone lactonohydrolase activity |
| CC | TAS | GO:0005576 | extracellular region |
Gene expression in normal tissue: PON2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PON2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| wikipathways | WP136 | Phase I biotransformations, non P450 |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PON2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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