PON2


Summary: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
paraoxonase 2MIM:602447Ensembl:ENSG00000105854HGNC:HGNC:9205PA335307q21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in PON2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004064arylesterase activity
MFIBAGO:0016788hydrolase activity, acting on ester bonds
MFIDAGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
MFTASGO:0102007acyl-L-homoserine-lactone lactonohydrolase activity
CCTASGO:0005576extracellular region
CCIEAGO:0005634nucleus
CCIEAGO:0005739mitochondrion
CCIEAGO:0005764lysosome
CCIDAGO:0005886plasma membrane
BPIEAGO:0006979response to oxidative stress
BPIBAGO:0009636response to toxic substance
BPTASGO:0019372lipoxygenase pathway
BPIDAGO:0019439aromatic compound catabolic process

Gene expression in normal tissue: PON2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PON2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-2142688Synthesis of 5-eicosatetraenoic acids
reactomeR-HSA-2142753Arachidonic acid metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8978868Fatty acid metabolism
wikipathwaysWP136Phase I biotransformations, non P450

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PON2

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