POU4F1
Summary: This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601632 Ensembl IDEnsembl:ENSG00000152192 HGNC IDHGNC:HGNC:9218 PHARMGKB IDPA33542 Map Location13q31.1 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in POU4F1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001967 | suckling behavior |
| BP | IEA | GO:0003223 | ventricular compact myocardium morphogenesis |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007409 | axonogenesis |
| BP | TAS | GO:0007416 | synapse assembly |
Gene expression in normal tissue: POU4F1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POU4F1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | p53downstreampathway | Direct p53 effectors |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POU4F1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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