Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008].

UDP glucuronosyltransferase family 1 member A6MIM:606431Ensembl:ENSG00000167165HGNC:HGNC:12538PA371812q37.1

Gene Categories:


GO terms in UGT1A6

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006805xenobiotic metabolic process
BPIDAGO:0052695cellular glucuronidation
BPTASGO:0052695cellular glucuronidation
BPIBAGO:0052696flavonoid glucuronidation
BPIBAGO:0052697xenobiotic glucuronidation
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043231intracellular membrane-bounded organelle
MFIDAGO:0001972retinoic acid binding
MFIBAGO:0008194UDP-glycosyltransferase activity
MFIDAGO:0015020glucuronosyltransferase activity
MFTASGO:0015020glucuronosyltransferase activity
MFIDAGO:0042803protein homodimerization activity
MFIDAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: UGT1A6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UGT1A6

DatabasePathway IDPathway Des.
pharmgkbPA145011115Phenytoin Pathway, Pharmacokinetics
pharmgkbPA165964265Valproic Acid Pathway, Pharmacokinetics
pharmgkbPA165986194Pathway_PA165986194 -need delete
pharmgkbPA165986279Acetaminophen Pathway, Pharmacokinetics
pharmgkbPA2029Irinotecan Pathway, Pharmacodynamics
humancycPWY66-201nicotine degradation IV
humancycPWY66-221nicotine degradation III
kegghsa00040Pentose and glucuronate interconversions - Homo sapiens (human)
kegghsa00053Ascorbate and aldarate metabolism - Homo sapiens (human)
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa00830Retinol metabolism - Homo sapiens (human)
kegghsa00860Porphyrin and chlorophyll metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa00983Drug metabolism - other enzymes - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
wikipathwaysWP1604Codeine and Morphine Metabolism
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP408Oxidative Stress
wikipathwaysWP697Estrogen metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00640Acetaminophen Metabolism Pathway
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-211859Biological oxidations
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UGT1A6