DDX56


Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DEAD-box helicase 56MIM:608023Ensembl:ENSG00000136271HGNC:HGNC:18193PA1349163467p13

GO terms in DDX56


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFTASGO:0004004ATP-dependent RNA helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
CCIDAGO:0005730nucleolus
CCHDAGO:0016020membrane
BPIEAGO:0010976positive regulation of neuron projection development

Gene expression in normal tissue: DDX56

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX56


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX56

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