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DDX56

Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
DEAD-box helicase 56	MIM:608023	Ensembl:ENSG00000136271	HGNC:HGNC:18193	PA134916346	7p13

GO terms in DDX56

Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	TAS	GO:0004004	ATP-dependent RNA helicase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
CC	IDA	GO:0005730	nucleolus
CC	HDA	GO:0016020	membrane
BP	IEA	GO:0010976	positive regulation of neuron projection development

Gene expression in normal tissue: DDX56

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDX56

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDX56

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CLASSFICATION

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