PPIB
Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| peptidylprolyl isomerase B | MIM:123841 | Ensembl:ENSG00000166794 | HGNC:HGNC:9255 | PA33580 | 15q22.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PPIB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | NAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IBA | GO:0005790 | smooth endoplasmic reticulum |
| CC | IEA | GO:0005790 | smooth endoplasmic reticulum |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IEA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IEA | GO:0042470 | melanosome |
| CC | IBA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0000413 | protein peptidyl-prolyl isomerization |
| BP | ISS | GO:0000413 | protein peptidyl-prolyl isomerization |
| BP | IBA | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IMP | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IBA | GO:0044794 | positive regulation by host of viral process |
| BP | IMP | GO:0044794 | positive regulation by host of viral process |
| BP | IBA | GO:0044829 | positive regulation by host of viral genome replication |
| BP | IMP | GO:0044829 | positive regulation by host of viral genome replication |
| BP | IBA | GO:0050821 | protein stabilization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IBA | GO:0060348 | bone development |
| BP | IMP | GO:0060348 | bone development |
| BP | IBA | GO:0061077 | chaperone-mediated protein folding |
| BP | IDA | GO:0061077 | chaperone-mediated protein folding |
| BP | IMP | GO:0061077 | chaperone-mediated protein folding |
| BP | IBA | GO:1901873 | regulation of post-translational protein modification |
| BP | IMP | GO:1901873 | regulation of post-translational protein modification |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IDA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | ISS | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | NAS | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005518 | collagen binding |
| MF | ISS | GO:0005518 | collagen binding |
| MF | IDA | GO:0016018 | cyclosporin A binding |
| MF | ISS | GO:0044877 | protein-containing complex binding |
| MF | IBA | GO:0051082 | unfolded protein binding |
| MF | TAS | GO:0051082 | unfolded protein binding |
| MF | IPI | GO:0070063 | RNA polymerase binding |
Gene expression in normal tissue: PPIB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPIB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1650814 | Collagen biosynthesis and modifying enzymes |
| smpdb | SMP00074 | Retinol Metabolism |
| smpdb | SMP00086 | Ibuprofen Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00336 | Vitamin A Deficiency |
| smpdb | SMP00406 | Morphine Action Pathway |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00590 | Ibuprofen Metabolism Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00622 | Morphine Metabolism Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| smpdb | SMP00648 | Sorafenib Metabolism Pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| netpath | Pathway_Prolactin | Prolactin |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPIB
CLASSFICATION
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