Summary: The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016].

transient receptor potential cation channel subfamily M member 4MIM:606936Ensembl:ENSG00000130529HGNC:HGNC:17993PA3827219q13.33

GO terms in TRPM4

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005227calcium activated cation channel activity
MFISSGO:0005227calcium activated cation channel activity
MFIEAGO:0005262calcium channel activity
MFTASGO:0005272sodium channel activity
MFIDAGO:0005509calcium ion binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
BPIEAGO:0002250adaptive immune response
BPISSGO:0002407dendritic cell chemotaxis
BPIDAGO:0002724regulation of T cell cytokine production
BPISSGO:0007204positive regulation of cytosolic calcium ion concentration
BPIDAGO:0008284positive regulation of cell proliferation
BPISSGO:0010460positive regulation of heart rate
BPIDAGO:0016925protein sumoylation
BPIDAGO:0019722calcium-mediated signaling
BPISSGO:0030502negative regulation of bone mineralization
BPISSGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus
BPISSGO:0045600positive regulation of fat cell differentiation
BPISSGO:0045668negative regulation of osteoblast differentiation
BPISSGO:0045907positive regulation of vasoconstriction
BPIDAGO:0051289protein homotetramerization
BPTASGO:0070588calcium ion transmembrane transport
BPIEAGO:0071318cellular response to ATP
BPIMPGO:0086045membrane depolarization during AV node cell action potential
BPIMPGO:0086047membrane depolarization during Purkinje myocyte cell action potential
BPIMPGO:0086048membrane depolarization during bundle of His cell action potential
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIDAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIDAGO:0098662inorganic cation transmembrane transport
BPIDAGO:0098719sodium ion import across plasma membrane
BPIMPGO:0098911regulation of ventricular cardiac muscle cell action potential
BPISSGO:1903949positive regulation of atrial cardiac muscle cell action potential
BPISSGO:1904179positive regulation of adipose tissue development
BPISSGO:1904199positive regulation of regulation of vascular smooth muscle cell membrane depolarization
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0034706sodium channel complex
CCISSGO:0043025neuronal cell body
CCIDAGO:0044214spanning component of plasma membrane
CCIDAGO:0089717spanning component of membrane

Gene expression in normal tissue: TRPM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRPM4

DatabasePathway IDPathway Des.
kegghsa04911Insulin secretion - Homo sapiens (human)
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-3295583TRP channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRPM4