TRPM4
Summary: The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transient receptor potential cation channel subfamily M member 4 | MIM:606936 | Ensembl:ENSG00000130529 | HGNC:HGNC:17993 | PA38272 | 19q13.33 |
GO terms in TRPM4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005227 | calcium activated cation channel activity |
| MF | ISS | GO:0005227 | calcium activated cation channel activity |
| MF | IEA | GO:0005262 | calcium channel activity |
| MF | TAS | GO:0005272 | sodium channel activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002407 | dendritic cell chemotaxis |
| BP | IDA | GO:0002724 | regulation of T cell cytokine production |
| BP | ISS | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0010460 | positive regulation of heart rate |
| BP | IDA | GO:0016925 | protein sumoylation |
| BP | IDA | GO:0019722 | calcium-mediated signaling |
| BP | ISS | GO:0030502 | negative regulation of bone mineralization |
| BP | ISS | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0042310 | vasoconstriction |
| BP | ISS | GO:0045600 | positive regulation of fat cell differentiation |
| BP | ISS | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | ISS | GO:0045907 | positive regulation of vasoconstriction |
| BP | IDA | GO:0051289 | protein homotetramerization |
| BP | TAS | GO:0070588 | calcium ion transmembrane transport |
| BP | IEA | GO:0071318 | cellular response to ATP |
| BP | IMP | GO:0086045 | membrane depolarization during AV node cell action potential |
| BP | IMP | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential |
| BP | IMP | GO:0086048 | membrane depolarization during bundle of His cell action potential |
| BP | IMP | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | IDA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:0098662 | inorganic cation transmembrane transport |
| BP | IDA | GO:0098719 | sodium ion import across plasma membrane |
| BP | IMP | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
| BP | ISS | GO:1903949 | positive regulation of atrial cardiac muscle cell action potential |
| BP | ISS | GO:1904179 | positive regulation of adipose tissue development |
| BP | ISS | GO:1904199 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0034706 | sodium channel complex |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0044214 | spanning component of plasma membrane |
| CC | IDA | GO:0089717 | spanning component of membrane |
Gene expression in normal tissue: TRPM4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPM4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPM4
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.