TRPM4
Summary: The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606936 Ensembl IDEnsembl:ENSG00000130529 HGNC IDHGNC:HGNC:17993 PHARMGKB IDPA38272 Map Location19q13.33 | |||||
GO terms in TRPM4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005227 | calcium activated cation channel activity |
| MF | ISS | GO:0005227 | calcium activated cation channel activity |
| MF | IEA | GO:0005262 | calcium channel activity |
| MF | TAS | GO:0005272 | sodium channel activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005516 | calmodulin binding |
Gene expression in normal tissue: TRPM4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPM4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPM4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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