CDKAL1
Summary: The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CDK5 regulatory subunit associated protein 1 like 1 | MIM:611259 | Ensembl:ENSG00000145996 | HGNC:HGNC:21050 | PA134871999 | 6p22.3 |
GO terms in CDKAL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0035596 | methylthiotransferase activity |
| MF | EXP | GO:0035598 | N6-threonylcarbomyladenosine methylthiotransferase activity |
| MF | IBA | GO:0035598 | N6-threonylcarbomyladenosine methylthiotransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| MF | IEA | GO:0061712 | tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005791 | rough endoplasmic reticulum |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0006400 | tRNA modification |
| BP | ND | GO:0008150 | biological_process |
| BP | IBA | GO:0035600 | tRNA methylthiolation |
| BP | IEA | GO:0035600 | tRNA methylthiolation |
| BP | IEA | GO:1990145 | maintenance of translational fidelity |
Gene expression in normal tissue: CDKAL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKAL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6782315 | tRNA modification in the nucleus and cytosol |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKAL1
CLASSFICATION
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