CDKAL1
Summary: The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611259 Ensembl IDEnsembl:ENSG00000145996 HGNC IDHGNC:HGNC:21050 PHARMGKB IDPA134871999 Map Location6p22.3 | |||||
GO terms in CDKAL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0035596 | methylthiotransferase activity |
| MF | EXP | GO:0035598 | N6-threonylcarbomyladenosine methylthiotransferase activity |
| MF | IBA | GO:0035598 | N6-threonylcarbomyladenosine methylthiotransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CDKAL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKAL1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6782315 | tRNA modification in the nucleus and cytosol |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKAL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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