LPCAT2
Summary: This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612040 Ensembl IDEnsembl:ENSG00000087253 HGNC IDHGNC:HGNC:26032 PHARMGKB IDPA162394265 Map Location16q12.2 | |||||
GO terms in LPCAT2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IDA | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity |
| MF | ISS | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity |
| MF | ISS | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity |
Gene expression in normal tissue: LPCAT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LPCAT2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1482788 | Acyl chain remodelling of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LPCAT2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.