LPCAT2
Summary: This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysophosphatidylcholine acyltransferase 2 | MIM:612040 | Ensembl:ENSG00000087253 | HGNC:HGNC:26032 | PA162394265 | 16q12.2 |
GO terms in LPCAT2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0047144 | 2-acylglycerol-3-phosphate O-acyltransferase activity |
| MF | IDA | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity |
| MF | ISS | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity |
| MF | ISS | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | ISS | GO:0005795 | Golgi stack |
| CC | IDA | GO:0005811 | lipid droplet |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | ISS | GO:0006663 | platelet activating factor biosynthetic process |
| BP | IDA | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| BP | TAS | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| BP | ISS | GO:0061024 | membrane organization |
Gene expression in normal tissue: LPCAT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LPCAT2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1482788 | Acyl chain remodelling of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LPCAT2
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