Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].

WD repeat containing antisense to TP53MIM:612661Ensembl:ENSG00000141499HGNC:HGNC:25522PA16472756817p13.1

GO terms in WRAP53

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005697telomerase holoenzyme complex
CCIDAGO:0015030Cajal body
CCIMPGO:0015030Cajal body
CCIDAGO:0016604nuclear body
BPIDAGO:0007004telomere maintenance via telomerase
BPIMPGO:0007004telomere maintenance via telomerase
BPTASGO:0007004telomere maintenance via telomerase
BPIMPGO:0032203telomere formation via telomerase
BPIDAGO:0051973positive regulation of telomerase activity
BPIMPGO:0051973positive regulation of telomerase activity
BPIMPGO:0090666scaRNA localization to Cajal body
BPHMPGO:0090671telomerase RNA localization to Cajal body
BPIMPGO:0090671telomerase RNA localization to Cajal body
BPIMPGO:1904851positive regulation of establishment of protein localization to telomere
BPTASGO:1904867protein localization to Cajal body
MFIDAGO:0003723RNA binding
MFIPIGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0044877protein-containing complex binding
MFIPIGO:0051087chaperone binding
MFIPIGO:0070034telomerase RNA binding

Gene expression in normal tissue: WRAP53

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WRAP53

DatabasePathway IDPathway Des.
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-171319Telomere Extension By Telomerase
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-73886Chromosome Maintenance

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WRAP53