WRAP53
Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612661 Ensembl IDEnsembl:ENSG00000141499 HGNC IDHGNC:HGNC:25522 PHARMGKB IDPA164727568 Map Location17p13.1 | |||||
Gene Categories:
RNA DIRECTED DNA POLYMERASEGO terms in WRAP53
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005697 | telomerase holoenzyme complex |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0015030 | Cajal body |
| CC | IMP | GO:0015030 | Cajal body |
| CC | IDA | GO:0016604 | nuclear body |
Gene expression in normal tissue: WRAP53
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WRAP53
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-171319 | Telomere Extension By Telomerase |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WRAP53
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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