CDCA8


Summary: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cell division cycle associated 8MIM:609977Ensembl:ENSG00000134690HGNC:HGNC:14629PA262811p34.3

GO terms in CDCA8


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000775chromosome, centromeric region
CCIDAGO:0000775chromosome, centromeric region
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCTASGO:0005829cytosol
CCIEAGO:0010369chromocenter
CCIDAGO:0030496midbody
CCIBAGO:0032133chromosome passenger complex
CCIPIGO:0032133chromosome passenger complex
CCIDAGO:0032991protein-containing complex
CCIDAGO:0045171intercellular bridge
CCIBAGO:0051233spindle midzone
BPIBAGO:0000070mitotic sister chromatid segregation
BPIMPGO:0007080mitotic metaphase plate congression
BPIMPGO:0051276chromosome organization
BPIEAGO:0051301cell division
MFIPIGO:0005515protein binding

Gene expression in normal tissue: CDCA8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDCA8


DatabasePathway IDPathway Des.
reactomeR-HSA-141424Amplification of signal from the kinetochores
reactomeR-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2500257Resolution of Sister Chromatid Cohesion
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69618Mitotic Spindle Checkpoint
reactomeR-HSA-69620Cell Cycle Checkpoints
pidaurora_b_pathwayAurora B signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDCA8

​​​​