CDCA8
Summary: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle associated 8 | MIM:609977 | Ensembl:ENSG00000134690 | HGNC:HGNC:14629 | PA26281 | 1p34.3 |
GO terms in CDCA8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000775 | chromosome, centromeric region |
| CC | IDA | GO:0000775 | chromosome, centromeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0010369 | chromocenter |
| CC | IDA | GO:0030496 | midbody |
| CC | IBA | GO:0032133 | chromosome passenger complex |
| CC | IPI | GO:0032133 | chromosome passenger complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | IBA | GO:0051233 | spindle midzone |
| BP | IBA | GO:0000070 | mitotic sister chromatid segregation |
| BP | IMP | GO:0007080 | mitotic metaphase plate congression |
| BP | IMP | GO:0051276 | chromosome organization |
| BP | IEA | GO:0051301 | cell division |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CDCA8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDCA8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| pid | aurora_b_pathway | Aurora B signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDCA8
CLASSFICATION
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