PPP2R1A
Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 2 scaffold subunit Aalpha | MIM:605983 | Ensembl:ENSG00000105568 | HGNC:HGNC:9302 | PA33666 | 19q13.41 |
GO terms in PPP2R1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IEA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019888 | protein phosphatase regulator activity |
| MF | TAS | GO:0019888 | protein phosphatase regulator activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:1990405 | protein antigen binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | NAS | GO:0000188 | inactivation of MAPK activity |
| BP | NAS | GO:0006275 | regulation of DNA replication |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006470 | protein dephosphorylation |
| BP | NAS | GO:0006672 | ceramide metabolic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007059 | chromosome segregation |
| BP | IEA | GO:0007143 | female meiotic nuclear division |
| BP | NAS | GO:0008380 | RNA splicing |
| BP | NAS | GO:0010033 | response to organic substance |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | NAS | GO:0019932 | second-messenger-mediated signaling |
| BP | NAS | GO:0030111 | regulation of Wnt signaling pathway |
| BP | NAS | GO:0030155 | regulation of cell adhesion |
| BP | NAS | GO:0030308 | negative regulation of cell growth |
| BP | NAS | GO:0040008 | regulation of growth |
| BP | NAS | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| BP | NAS | GO:0045595 | regulation of cell differentiation |
| BP | IEA | GO:0051232 | meiotic spindle elongation |
| BP | IEA | GO:0051306 | mitotic sister chromatid separation |
| BP | IEA | GO:0051754 | meiotic sister chromatid cohesion, centromeric |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0070262 | peptidyl-serine dephosphorylation |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IEA | GO:1903538 | regulation of meiotic cell cycle process involved in oocyte maturation |
| BP | IEA | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IBA | GO:0000159 | protein phosphatase type 2A complex |
| CC | IDA | GO:0000159 | protein phosphatase type 2A complex |
| CC | TAS | GO:0000159 | protein phosphatase type 2A complex |
| CC | IDA | GO:0000775 | chromosome, centromeric region |
| CC | NAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0008287 | protein serine/threonine phosphatase complex |
| CC | NAS | GO:0015630 | microtubule cytoskeleton |
| CC | NAS | GO:0016020 | membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PPP2R1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP2R1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196299 | Beta-catenin phosphorylation cascade |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2995383 | Initiation of Nuclear Envelope Reformation |
| reactome | R-HSA-2995410 | Nuclear Envelope Reassembly |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-432142 | Platelet sensitization by LDL |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-4839735 | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| reactome | R-HSA-4839743 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| reactome | R-HSA-4839744 | truncated APC mutants destabilize the destruction complex |
| reactome | R-HSA-4839748 | AMER1 mutants destabilize the destruction complex |
| reactome | R-HSA-5339716 | Misspliced GSK3beta mutants stabilize beta-catenin |
| reactome | R-HSA-5358747 | S33 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358749 | S37 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358751 | S45 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358752 | T41 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5467337 | APC truncation mutants have impaired AXIN binding |
| reactome | R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex |
| reactome | R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5673000 | RAF activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP500 | Glycogen Metabolism |
| kegg | hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| pid | atr_pathway | ATR signaling pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | plk1_pathway | PLK1 signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD378 | ZM-447439 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP2R1A
CLASSFICATION
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