Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

protein phosphatase 2 regulatory subunit BgammaMIM:605997Ensembl:ENSG00000074211HGNC:HGNC:9306PA336704p16.1

Gene Categories:


GO terms in PPP2R2C

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004722protein serine/threonine phosphatase activity
MFIPIGO:0005515protein binding
MFNASGO:0019888protein phosphatase regulator activity
BPIBAGO:0000278mitotic cell cycle
BPIBAGO:0032502developmental process
BPIEAGO:0043666regulation of phosphoprotein phosphatase activity
BPIBAGO:0070262peptidyl-serine dephosphorylation
CCIBAGO:0000159protein phosphatase type 2A complex
CCNASGO:0000159protein phosphatase type 2A complex

Gene expression in normal tissue: PPP2R2C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP2R2C

DatabasePathway IDPathway Des.
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP500Glycogen Metabolism
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP2R2C