PPP2R2C


Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

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Gene Categories:

PROTEIN PHOSPHATASE

GO terms in PPP2R2C


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004722 protein serine/threonine phosphatase activity
MF IPI GO:0005515 protein binding
MF NAS GO:0019888 protein phosphatase regulator activity
BP IBA GO:0000278 mitotic cell cycle
BP IBA GO:0032502 developmental process
BP IEA GO:0043666 regulation of phosphoprotein phosphatase activity
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Gene expression in normal tissue: PPP2R2C

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in PPP2R2C


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Database
Pathway ID
Pathway Des.
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP399 Wnt Signaling Pathway and Pluripotency
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP500 Glycogen Metabolism
kegg hsa03015 mRNA surveillance pathway - Homo sapiens (human)
kegg hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP2R2C

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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