USP40
Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610570 Ensembl IDEnsembl:ENSG00000085982 HGNC IDHGNC:HGNC:20069 PHARMGKB IDPA134909324 Map Location2q37.1 | |||||
GO terms in USP40
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IBA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IEA | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0016579 | protein deubiquitination |
| BP | IEA | GO:0016579 | protein deubiquitination |
Gene expression in normal tissue: USP40
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in USP40
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in USP40
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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