STEAP3
Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609671 Ensembl IDEnsembl:ENSG00000115107 HGNC IDHGNC:HGNC:24592 PHARMGKB IDPA142670863 Map Location2q14.2 |
GO terms in STEAP3
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008823 | cupric reductase activity |
MF | TAS | GO:0016723 | oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor |
MF | IEA | GO:0046872 | metal ion binding |
MF | IBA | GO:0052851 | ferric-chelate reductase (NADPH) activity |
BP | IEA | GO:0006915 | apoptotic process |
Gene expression in normal tissue: STEAP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STEAP3
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
reactome | R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in STEAP3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |