STEAP3


Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].

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PHARMGKB ID
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GO terms in STEAP3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0008823 cupric reductase activity
MF TAS GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
MF IEA GO:0046872 metal ion binding
MF IBA GO:0052851 ferric-chelate reductase (NADPH) activity
BP IEA GO:0006915 apoptotic process
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Gene expression in normal tissue: STEAP3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in STEAP3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3700989 Transcriptional Regulation by TP53
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
reactome R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactome R-HSA-73857 RNA Polymerase II Transcription
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STEAP3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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