DRAM1
Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA damage regulated autophagy modulator 1 | MIM:610776 | Ensembl:ENSG00000136048 | HGNC:HGNC:25645 | PA165512564 | 12q23.2 |
GO terms in DRAM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | IEA | GO:0005765 | lysosomal membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0006914 | autophagy |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IBA | GO:0010506 | regulation of autophagy |
| BP | IDA | GO:0010506 | regulation of autophagy |
Gene expression in normal tissue: DRAM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DRAM1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DRAM1
CLASSFICATION
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