PRCC
Summary: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| proline rich mitotic checkpoint control factor | MIM:179755 | Ensembl:ENSG00000143294 | HGNC:HGNC:9343 | PA33704 | 1q23.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in PRCC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0007093 | mitotic cell cycle checkpoint |
Gene expression in normal tissue: PRCC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRCC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD802 | 4-methylfasudil | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRCC
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.