SOX6


Summary: This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SRY-box 6MIM:607257Ensembl:ENSG00000110693HGNC:HGNC:16421PA3813711p15.2

GO terms in SOX6


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0007399nervous system development
BPIBAGO:0007417central nervous system development
BPNASGO:0007517muscle organ development
BPIEAGO:0009791post-embryonic development
BPIEAGO:0016458gene silencing
BPIEAGO:0021778oligodendrocyte cell fate specification
BPIBAGO:0032332positive regulation of chondrocyte differentiation
BPIDAGO:0032332positive regulation of chondrocyte differentiation
BPIBAGO:0045165cell fate commitment
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048708astrocyte differentiation
BPIEAGO:0048821erythrocyte development
BPIEAGO:0051216cartilage development
BPIEAGO:0055007cardiac muscle cell differentiation
BPIDAGO:0061036positive regulation of cartilage development
BPIDAGO:0071560cellular response to transforming growth factor beta stimulus
BPIMPGO:2000726negative regulation of cardiac muscle cell differentiation
BPIDAGO:2000741positive regulation of mesenchymal stem cell differentiation
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFNASGO:0003677DNA binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: SOX6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX6


DatabasePathway IDPathway Des.
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP474Endochondral Ossification
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX6

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