OTUD5
Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| OTU deubiquitinase 5 | MIM:300713 | Ensembl:ENSG00000068308 | HGNC:HGNC:25402 | PA142671217 | Xp11.23 |
GO terms in OTUD5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | EXP | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | IDA | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | IDA | GO:0101005 | ubiquitinyl hydrolase activity |
| MF | IDA | GO:1990380 | Lys48-specific deubiquitinase activity |
| BP | IDA | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0032480 | negative regulation of type I interferon production |
| BP | IDA | GO:0032496 | response to lipopolysaccharide |
| BP | IDA | GO:0070536 | protein K63-linked deubiquitination |
| BP | IDA | GO:0071108 | protein K48-linked deubiquitination |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: OTUD5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OTUD5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OTUD5
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