OTUD5


Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
OTU deubiquitinase 5MIM:300713Ensembl:ENSG00000068308HGNC:HGNC:25402PA142671217Xp11.23

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in OTUD5


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFEXPGO:0061578Lys63-specific deubiquitinase activity
MFIDAGO:0061578Lys63-specific deubiquitinase activity
MFIDAGO:0101005ubiquitinyl hydrolase activity
MFIDAGO:1990380Lys48-specific deubiquitinase activity
BPIDAGO:0016579protein deubiquitination
BPTASGO:0016579protein deubiquitination
BPTASGO:0032480negative regulation of type I interferon production
BPIDAGO:0032496response to lipopolysaccharide
BPIDAGO:0070536protein K63-linked deubiquitination
BPIDAGO:0071108protein K48-linked deubiquitination
CCTASGO:0005829cytosol

Gene expression in normal tissue: OTUD5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OTUD5


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689896Ovarian tumor domain proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-936440Negative regulators of DDX58/IFIH1 signaling
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2363Gastric Cancer Network 2
wikipathwaysWP3865RIG-I-like Receptor Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OTUD5

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