Summary: This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009].

fermitin family member 1MIM:607900Ensembl:ENSG00000101311HGNC:HGNC:15889PA16238831420p12.3

GO terms in FERMT1

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001954positive regulation of cell-matrix adhesion
BPIDAGO:0007155cell adhesion
BPIEAGO:0007229integrin-mediated signaling pathway
BPIEAGO:0010629negative regulation of gene expression
BPIEAGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIEAGO:0033630positive regulation of cell adhesion mediated by integrin
BPIEAGO:0042308negative regulation of protein import into nucleus
BPIDAGO:0043616keratinocyte proliferation
BPIDAGO:0051546keratinocyte migration
BPIEAGO:0051886negative regulation of timing of anagen
BPIEAGO:0071711basement membrane organization
BPIEAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIDAGO:0090162establishment of epithelial cell polarity
BPIEAGO:2000647negative regulation of stem cell proliferation
BPIEAGO:2001203positive regulation of transforming growth factor-beta secretion
CCIEAGO:0005925focal adhesion
CCIDAGO:0030054cell junction
CCIEAGO:0031941filamentous actin
CCIEAGO:0032587ruffle membrane

Gene expression in normal tissue: FERMT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FERMT1

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FERMT1