FERMT1
Summary: This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607900 Ensembl IDEnsembl:ENSG00000101311 HGNC IDHGNC:HGNC:15889 PHARMGKB IDPA162388314 Map Location20p12.3 | |||||
GO terms in FERMT1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0033630 | positive regulation of cell adhesion mediated by integrin |
Gene expression in normal tissue: FERMT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FERMT1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 4 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FERMT1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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