FERMT1


Summary: This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009].

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GO terms in FERMT1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001954 positive regulation of cell-matrix adhesion
BP IDA GO:0007155 cell adhesion
BP IEA GO:0007229 integrin-mediated signaling pathway
BP IEA GO:0010629 negative regulation of gene expression
BP IEA GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
BP IEA GO:0033630 positive regulation of cell adhesion mediated by integrin
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Gene expression in normal tissue: FERMT1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in FERMT1


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Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FERMT1

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No matching records found

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