PRKACB


Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].

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GO terms in PRKACB


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001843 neural tube closure
BP TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway
BP TAS GO:0003091 renal water homeostasis
BP IDA GO:0006468 protein phosphorylation
BP TAS GO:0007165 signal transduction
BP TAS GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: PRKACB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined20PI3K/MTOR signaling2Mitosis1Longevity regulating pathway1Chromatin histone acetylation1Apoptosis regulation1Other, kinases1ERK MAPK signaling1

Pathways in PRKACB


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Database
Pathway ID
Pathway Des.
biocarta agpcrpathway attenuation of gpcr signaling
biocarta akap13pathway rho-selective guanine exchange factor akap13 mediates stress fiber formation
biocarta akap95pathway akap95 role in mitosis and chromosome dynamics
biocarta akapcentrosomepathway protein kinase a at the centrosome
biocarta badpathway regulation of bad phosphorylation
biocarta carm1pathway transcription regulation by methyltransferase of carm1
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
iGMDRD121 GMX1778 2
iGMDRD137 Indisulam 1
iGMDRD885 Compound 110 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKACB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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