Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].

protein kinase cAMP-activated catalytic subunit betaMIM:176892Ensembl:ENSG00000142875HGNC:HGNC:9381PA337491p31.1

GO terms in PRKACB

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001843neural tube closure
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0003091renal water homeostasis
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPTASGO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway
BPTASGO:0007596blood coagulation
BPTASGO:0034199activation of protein kinase A activity
BPTASGO:0034380high-density lipoprotein particle assembly
BPIEAGO:0051447negative regulation of meiotic cell cycle
BPIEAGO:0070613regulation of protein processing
BPTASGO:0071377cellular response to glucagon stimulus
BPIEAGO:0097338response to clozapine
BPIEAGO:1901621negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
CCIEAGO:0005886plasma membrane
CCTASGO:0005952cAMP-dependent protein kinase complex
CCIDAGO:0045171intercellular bridge
CCIEAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCTASGO:0097546ciliary base
MFIDAGO:0000287magnesium ion binding
MFEXPGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004691cAMP-dependent protein kinase activity
MFTASGO:0004691cAMP-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFTASGO:0016301kinase activity
MFIDAGO:0031625ubiquitin protein ligase binding

Gene expression in normal tissue: PRKACB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKACB

DatabasePathway IDPathway Des.
biocartaagpcrpathwayattenuation of gpcr signaling
biocartaakap13pathwayrho-selective guanine exchange factor akap13 mediates stress fiber formation
biocartaakap95pathwayakap95 role in mitosis and chromosome dynamics
biocartaakapcentrosomepathwayprotein kinase a at the centrosome
biocartabadpathwayregulation of bad phosphorylation
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartacftrpathwaycystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartadreampathwayrepression of pain sensation by the transcriptional regulator dream
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartagpcrpathwaysignaling pathway from g-protein families
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamprpathwayhow progesterone initiates the oocyte maturation
biocartano1pathwayactions of nitric oxide in the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartaplcepathwayphospholipase c-epsilon pathway
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111931PKA-mediated phosphorylation of CREB
reactomeR-HSA-111931PKA-mediated phosphorylation of CREB
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163358PKA-mediated phosphorylation of key metabolic factors
reactomeR-HSA-163359Glucagon signaling in metabolic regulation
reactomeR-HSA-163560Triglyceride catabolism
reactomeR-HSA-163615PKA activation
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-164378PKA activation in glucagon signalling
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-392517Rap1 signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-442720CREB phosphorylation through the activation of Adenylate Cyclase
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-8963896HDL assembly
reactomeR-HSA-8963898Plasma lipoprotein assembly
reactomeR-HSA-8979227Triglyceride metabolism
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9010642ROBO receptors bind AKAP5
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
smpdbSMP00308Dopamine Activation of Neurological Reward System
smpdbSMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
smpdbSMP00310Corticotropin Activation of Cortisol Production
smpdbSMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
smpdbSMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00322Vasopressin Regulation of Water Homeostasis
smpdbSMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdbSMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
smpdbSMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdbSMP00343Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
smpdbSMP00354Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2436Dopamine metabolism
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil3_pathwayIL3-mediated signaling events
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
pidp73pathwayp73 transcription factor network
pidp75ntrpathwayp75(NTR)-mediated signaling
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04742Taste transduction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04913Ovarian steroidogenesis - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)
kegghsa05012Parkinson,s disease - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05110Vibrio cholerae infection - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1103
iGMDRD286Nsc 6328392
iGMDRD887Compound 23 citrate2
iGMDRD61Kinetin riboside2
iGMDRD297Austocystin D5
iGMDRD679Bistramide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKACB