PRKACB
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase cAMP-activated catalytic subunit beta | MIM:176892 | Ensembl:ENSG00000142875 | HGNC:HGNC:9381 | PA33749 | 1p31.1 |
GO terms in PRKACB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001843 | neural tube closure |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | TAS | GO:0003091 | renal water homeostasis |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0034199 | activation of protein kinase A activity |
| BP | TAS | GO:0034380 | high-density lipoprotein particle assembly |
| BP | IEA | GO:0051447 | negative regulation of meiotic cell cycle |
| BP | IEA | GO:0070613 | regulation of protein processing |
| BP | TAS | GO:0071377 | cellular response to glucagon stimulus |
| BP | IEA | GO:0097338 | response to clozapine |
| BP | IEA | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0097546 | ciliary base |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004691 | cAMP-dependent protein kinase activity |
| MF | TAS | GO:0004691 | cAMP-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
Gene expression in normal tissue: PRKACB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKACB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | agpcrpathway | attenuation of gpcr signaling |
| biocarta | akap13pathway | rho-selective guanine exchange factor akap13 mediates stress fiber formation |
| biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | cftrpathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | plcepathway | phospholipase c-epsilon pathway |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors |
| reactome | R-HSA-163359 | Glucagon signaling in metabolic regulation |
| reactome | R-HSA-163560 | Triglyceride catabolism |
| reactome | R-HSA-163615 | PKA activation |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-164378 | PKA activation in glucagon signalling |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392517 | Rap1 signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-442720 | CREB phosphorylation through the activation of Adenylate Cyclase |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-445717 | Aquaporin-mediated transport |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5610780 | Degradation of GLI1 by the proteasome |
| reactome | R-HSA-5610783 | Degradation of GLI2 by the proteasome |
| reactome | R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621575 | CD209 (DC-SIGN) signaling |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8963896 | HDL assembly |
| reactome | R-HSA-8963898 | Plasma lipoprotein assembly |
| reactome | R-HSA-8979227 | Triglyceride metabolism |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9010642 | ROBO receptors bind AKAP5 |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| smpdb | SMP00308 | Dopamine Activation of Neurological Reward System |
| smpdb | SMP00309 | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin |
| smpdb | SMP00310 | Corticotropin Activation of Cortisol Production |
| smpdb | SMP00311 | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin |
| smpdb | SMP00312 | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00322 | Vasopressin Regulation of Water Homeostasis |
| smpdb | SMP00333 | Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone |
| smpdb | SMP00335 | Intracellular Signalling Through Histamine H2 Receptor and Histamine |
| smpdb | SMP00338 | Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin |
| smpdb | SMP00343 | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 |
| smpdb | SMP00354 | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2436 | Dopamine metabolism |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | p73pathway | p73 transcription factor network |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD679 | Bistramide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKACB
CLASSFICATION
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