PRKACB
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:176892 Ensembl IDEnsembl:ENSG00000142875 HGNC IDHGNC:HGNC:9381 PHARMGKB IDPA33749 Map Location1p31.1 |
GO terms in PRKACB
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001843 | neural tube closure |
BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
BP | TAS | GO:0003091 | renal water homeostasis |
BP | IDA | GO:0006468 | protein phosphorylation |
BP | TAS | GO:0007165 | signal transduction |
BP | TAS | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway |
Gene expression in normal tissue: PRKACB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKACB
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Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | agpcrpathway | attenuation of gpcr signaling |
biocarta | akap13pathway | rho-selective guanine exchange factor akap13 mediates stress fiber formation |
biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
biocarta | badpathway | regulation of bad phosphorylation |
biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKACB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |