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PRKACB

Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameprotein kinase cAMP-activated catalytic subunit beta OMIM IDMIM:176892 Ensembl IDEnsembl:ENSG00000142875 HGNC IDHGNC:HGNC:9381 PHARMGKB IDPA33749 Map Location1p31.1

Gene Categories:

SERINE THREONINE KINASE TUMOR SUPPRESSOR KINASE DRUGGABLE GENOME

GO terms in PRKACB

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001843	neural tube closure
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	TAS	GO:0003091	renal water homeostasis
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0007165	signal transduction
BP	TAS	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway

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Gene expression in normal tissue: PRKACB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKACB

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Database	Pathway ID	Pathway Des.
biocarta	agpcrpathway	attenuation of gpcr signaling
biocarta	akap13pathway	rho-selective guanine exchange factor akap13 mediates stress fiber formation
biocarta	akap95pathway	akap95 role in mitosis and chromosome dynamics
biocarta	akapcentrosomepathway	protein kinase a at the centrosome
biocarta	badpathway	regulation of bad phosphorylation
biocarta	carm1pathway	transcription regulation by methyltransferase of carm1

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD255	SB225002	3
iGMDRD121	GMX1778	2
iGMDRD137	Indisulam	1
iGMDRD885	Compound 110	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKACB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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