PRKAR1A
Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:188830 Ensembl IDEnsembl:ENSG00000108946 HGNC IDHGNC:HGNC:9388 PHARMGKB IDPA33754 Map Location17q24.2 |
GO terms in PRKAR1A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0008603 | cAMP-dependent protein kinase regulator activity |
MF | IPI | GO:0019904 | protein domain specific binding |
MF | IEA | GO:0030552 | cAMP binding |
MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
Gene expression in normal tissue: PRKAR1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAR1A
Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_EGFR1 | EGFR1 |
pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
wikipathways | WP2857 | Mesodermal Commitment Pathway |
wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAR1A
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |