Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].

protein kinase cAMP-dependent type I regulatory subunit alphaMIM:188830Ensembl:ENSG00000108946HGNC:HGNC:9388PA3375417q24.2

GO terms in PRKAR1A

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004862cAMP-dependent protein kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008603cAMP-dependent protein kinase regulator activity
MFIPIGO:0019904protein domain specific binding
MFIEAGO:0030552cAMP binding
MFIDAGO:0031625ubiquitin protein ligase binding
MFIPIGO:0034236protein kinase A catalytic subunit binding
MFIBAGO:00475553',5'-cyclic-GMP phosphodiesterase activity
CCIDAGO:0001772immunological synapse
CCIEAGO:0005952cAMP-dependent protein kinase complex
CCIDAGO:0031588nucleotide-activated protein kinase complex
CCIEAGO:0031594neuromuscular junction
CCIDAGO:0032991protein-containing complex
CCIDAGO:0044853plasma membrane raft
CCTASGO:0097546ciliary base
BPIEAGO:0001707mesoderm formation
BPTASGO:0003091renal water homeostasis
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007143female meiotic nuclear division
BPTASGO:0007596blood coagulation
BPIBAGO:0019934cGMP-mediated signaling
BPTASGO:0034199activation of protein kinase A activity
BPTASGO:0035556intracellular signal transduction
BPIEAGO:0045214sarcomere organization
BPIEAGO:0045835negative regulation of meiotic nuclear division
BPIMPGO:0046007negative regulation of activated T cell proliferation
BPIEAGO:0060038cardiac muscle cell proliferation
BPTASGO:0071377cellular response to glucagon stimulus
BPIDAGO:2000480negative regulation of cAMP-dependent protein kinase activity

Gene expression in normal tissue: PRKAR1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKAR1A

DatabasePathway IDPathway Des.
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111931PKA-mediated phosphorylation of CREB
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163359Glucagon signaling in metabolic regulation
reactomeR-HSA-163615PKA activation
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-164378PKA activation in glucagon signalling
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
biocartaagpcrpathwayattenuation of gpcr signaling
biocartabadpathwayregulation of bad phosphorylation
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartacftrpathwaycystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartadreampathwayrepression of pain sensation by the transcriptional regulator dream
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartagpcrpathwaysignaling pathway from g-protein families
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamprpathwayhow progesterone initiates the oocyte maturation
biocartano1pathwayactions of nitric oxide in the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartaplcepathwayphospholipase c-epsilon pathway
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside3
iGMDRD446LY 21832402
iGMDRD341Triacsin c5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR1A