PRKAR1A


Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].

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GO terms in PRKAR1A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004862 cAMP-dependent protein kinase inhibitor activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008603 cAMP-dependent protein kinase regulator activity
MF IPI GO:0019904 protein domain specific binding
MF IEA GO:0030552 cAMP binding
MF IDA GO:0031625 ubiquitin protein ligase binding
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Gene expression in normal tissue: PRKAR1A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 16LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9

Gene-drug pathway distribution

undefined7Longevity regulating pathway1Insulin signaling pathway1

Pathways in PRKAR1A


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
pid integrin_a4b1_pathway Alpha4 beta1 integrin signaling events
kegg hsa04910 Insulin signaling pathway - Homo sapiens (human)
wikipathways WP2012 miRs in Muscle Cell Differentiation
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD513 BML-259 3
iGMDRD32 Metformin 1
iGMDRD781 Sirolimus 3
iGMDRD187 BRD9876 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR1A

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Cancer
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