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CHFR

Summary: This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecheckpoint with forkhead and ring finger domains OMIM IDMIM:605209 Ensembl IDEnsembl:ENSG00000072609 HGNC IDHGNC:HGNC:20455 PHARMGKB IDPA134898949 Map Location12q24.33

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CHFR

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0000166	nucleotide binding
MF	IBA	GO:0004842	ubiquitin-protein transferase activity
MF	IDA	GO:0004842	ubiquitin-protein transferase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0046872	metal ion binding
MF	IEA	GO:0061630	ubiquitin protein ligase activity

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Gene expression in normal tissue: CHFR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHFR

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHFR

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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