CHFR
Summary: This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| checkpoint with forkhead and ring finger domains | MIM:605209 | Ensembl:ENSG00000072609 | HGNC:HGNC:20455 | PA134898949 | 12q24.33 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CHFR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000166 | nucleotide binding |
| MF | IBA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0061630 | ubiquitin protein ligase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0016605 | PML body |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IMP | GO:0007093 | mitotic cell cycle checkpoint |
| BP | TAS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0019941 | modification-dependent protein catabolic process |
| BP | IEA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IEA | GO:0031648 | protein destabilization |
| BP | IEA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: CHFR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHFR
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHFR
CLASSFICATION
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