OGDHL
Summary: The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| oxoglutarate dehydrogenase like | MIM:617513 | Ensembl:ENSG00000197444 | HGNC:HGNC:25590 | PA134878907 | 10q11.23 |
GO terms in OGDHL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006096 | glycolytic process |
| BP | IBA | GO:0006099 | tricarboxylic acid cycle |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005829 | cytosol |
| CC | IBA | GO:0045252 | oxoglutarate dehydrogenase complex |
| MF | IBA | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030976 | thiamine pyrophosphate binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: OGDHL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OGDHL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OGDHL
CLASSFICATION
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