H2AFJ
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
GO terms in H2AFJ
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | IEA | GO:0000786 | nucleosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: H2AFJ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in H2AFJ
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157579 | Telomere Maintenance |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in H2AFJ
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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