PRKAR2B


Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].

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GO terms in PRKAR2B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004862 cAMP-dependent protein kinase inhibitor activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008603 cAMP-dependent protein kinase regulator activity
MF IEA GO:0019904 protein domain specific binding
MF IEA GO:0030552 cAMP binding
MF IDA GO:0031625 ubiquitin protein ligase binding
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Gene expression in normal tissue: PRKAR2B

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in PRKAR2B


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Database
Pathway ID
Pathway Des.
wikipathways WP2012 miRs in Muscle Cell Differentiation
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP35 G Protein Signaling Pathways
wikipathways WP3965 Lipid Metabolism Pathway
wikipathways WP4010 Liver steatosis AOP
wikipathways WP536 Calcium Regulation in the Cardiac Cell
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR2B

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Level
Reference ID
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Cancer
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No matching records found

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