Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].

protein kinase cAMP-dependent type II regulatory subunit betaMIM:176912Ensembl:ENSG00000005249HGNC:HGNC:9392PA337587q22.3

GO terms in PRKAR2B

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004862cAMP-dependent protein kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008603cAMP-dependent protein kinase regulator activity
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0030552cAMP binding
MFIDAGO:0031625ubiquitin protein ligase binding
MFIPIGO:0034236protein kinase A catalytic subunit binding
MFIBAGO:00475553',5'-cyclic-GMP phosphodiesterase activity
CCIEAGO:0005743mitochondrial inner membrane
CCIDAGO:0005886plasma membrane
CCIEAGO:0005952cAMP-dependent protein kinase complex
CCIEAGO:0043025neuronal cell body
CCISSGO:0043197dendritic spine
CCISSGO:0043198dendritic shaft
CCIEAGO:0045121membrane raft
CCIEAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCTASGO:0097546ciliary base
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0003091renal water homeostasis
BPIEAGO:0006631fatty acid metabolic process
BPTASGO:0007596blood coagulation
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIBAGO:0019934cGMP-mediated signaling
BPTASGO:0034199activation of protein kinase A activity
BPTASGO:0035556intracellular signal transduction
BPTASGO:0071377cellular response to glucagon stimulus
BPIEAGO:0097338response to clozapine
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPIDAGO:2000480negative regulation of cAMP-dependent protein kinase activity

Gene expression in normal tissue: PRKAR2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKAR2B

DatabasePathway IDPathway Des.
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
biocartaagpcrpathwayattenuation of gpcr signaling
biocartaakap13pathwayrho-selective guanine exchange factor akap13 mediates stress fiber formation
biocartaakap95pathwayakap95 role in mitosis and chromosome dynamics
biocartaakapcentrosomepathwayprotein kinase a at the centrosome
biocartabadpathwayregulation of bad phosphorylation
biocartacarm1pathwaytranscription regulation by methyltransferase of carm1
biocartacftrpathwaycystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartadreampathwayrepression of pain sensation by the transcriptional regulator dream
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartagpcrpathwaysignaling pathway from g-protein families
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamprpathwayhow progesterone initiates the oocyte maturation
biocartano1pathwayactions of nitric oxide in the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartaplcepathwayphospholipase c-epsilon pathway
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111931PKA-mediated phosphorylation of CREB
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163359Glucagon signaling in metabolic regulation
reactomeR-HSA-163615PKA activation
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-164378PKA activation in glucagon signalling
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8854518AURKA Activation by TPX2
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKAR2B