PRKAR2B
Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase cAMP-dependent type II regulatory subunit beta | MIM:176912 | Ensembl:ENSG00000005249 | HGNC:HGNC:9392 | PA33758 | 7q22.3 |
GO terms in PRKAR2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0030552 | cAMP binding |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0034236 | protein kinase A catalytic subunit binding |
| MF | IBA | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005952 | cAMP-dependent protein kinase complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | ISS | GO:0043198 | dendritic shaft |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0097546 | ciliary base |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0003091 | renal water homeostasis |
| BP | IEA | GO:0006631 | fatty acid metabolic process |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0007612 | learning |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0019934 | cGMP-mediated signaling |
| BP | TAS | GO:0034199 | activation of protein kinase A activity |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0071377 | cellular response to glucagon stimulus |
| BP | IEA | GO:0097338 | response to clozapine |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IDA | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity |
Gene expression in normal tissue: PRKAR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAR2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| biocarta | agpcrpathway | attenuation of gpcr signaling |
| biocarta | akap13pathway | rho-selective guanine exchange factor akap13 mediates stress fiber formation |
| biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | cftrpathway | cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | plcepathway | phospholipase c-epsilon pathway |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111931 | PKA-mediated phosphorylation of CREB |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163359 | Glucagon signaling in metabolic regulation |
| reactome | R-HSA-163615 | PKA activation |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-164378 | PKA activation in glucagon signalling |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins |
| reactome | R-HSA-445717 | Aquaporin-mediated transport |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAR2B
CLASSFICATION
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