PRKAR2B
Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:176912 Ensembl IDEnsembl:ENSG00000005249 HGNC IDHGNC:HGNC:9392 PHARMGKB IDPA33758 Map Location7q22.3 |
GO terms in PRKAR2B
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0008603 | cAMP-dependent protein kinase regulator activity |
MF | IEA | GO:0019904 | protein domain specific binding |
MF | IEA | GO:0030552 | cAMP binding |
MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
Gene expression in normal tissue: PRKAR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKAR2B
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
wikipathways | WP35 | G Protein Signaling Pathways |
wikipathways | WP3965 | Lipid Metabolism Pathway |
wikipathways | WP4010 | Liver steatosis AOP |
wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKAR2B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |