PRKCD
Summary: The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C delta | MIM:176977 | Ensembl:ENSG00000163932 | HGNC:HGNC:9399 | PA33763 | 3p21.1 |
GO terms in PRKCD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | EXP | GO:0004699 | calcium-independent protein kinase C activity |
| MF | TAS | GO:0004699 | calcium-independent protein kinase C activity |
| MF | IEA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008047 | enzyme activator activity |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0043560 | insulin receptor substrate binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| BP | TAS | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0016064 | immunoglobulin mediated immune response |
| BP | IDA | GO:0016572 | histone phosphorylation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0023021 | termination of signal transduction |
| BP | TAS | GO:0030168 | platelet activation |
| BP | ISS | GO:0030837 | negative regulation of actin filament polymerization |
| BP | IMP | GO:0032079 | positive regulation of endodeoxyribonuclease activity |
| BP | TAS | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032147 | activation of protein kinase activity |
| BP | IEA | GO:0032613 | interleukin-10 production |
| BP | IEA | GO:0032615 | interleukin-12 production |
| BP | IMP | GO:0032930 | positive regulation of superoxide anion generation |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0034351 | negative regulation of glial cell apoptotic process |
| BP | IMP | GO:0035307 | positive regulation of protein dephosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IEA | GO:0042100 | B cell proliferation |
| BP | IDA | GO:0042119 | neutrophil activation |
| BP | IMP | GO:0042307 | positive regulation of protein import into nucleus |
| BP | ISS | GO:0042742 | defense response to bacterium |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0043407 | negative regulation of MAP kinase activity |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | ISS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | TAS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | IC | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | NAS | GO:0050821 | protein stabilization |
| BP | ISS | GO:0051490 | negative regulation of filopodium assembly |
| BP | IMP | GO:0060326 | cell chemotaxis |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IDA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IDA | GO:0071447 | cellular response to hydroperoxide |
| BP | ISS | GO:0090331 | negative regulation of platelet aggregation |
| BP | IMP | GO:0090398 | cellular senescence |
| BP | IMP | GO:1900163 | positive regulation of phospholipid scramblase activity |
| BP | IDA | GO:1904385 | cellular response to angiotensin |
| BP | IMP | GO:2000304 | positive regulation of ceramide biosynthetic process |
| BP | IMP | GO:2000753 | positive regulation of glucosylceramide catabolic process |
| BP | IMP | GO:2000755 | positive regulation of sphingomyelin catabolic process |
| BP | IMP | GO:2001022 | positive regulation of response to DNA damage stimulus |
| BP | IEA | GO:2001235 | positive regulation of apoptotic signaling pathway |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PRKCD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-913531 | Interferon Signaling |
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | endothelinpathway | Endothelins |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | ifngpathway | IFN-gamma pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p53regulationpathway | p53 pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_Wnt | Wnt |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCD
CLASSFICATION
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