SCN3B


Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sodium voltage-gated channel beta subunit 3MIM:608214Ensembl:ENSG00000166257HGNC:HGNC:20665PA13054691211q24.1

GO terms in SCN3B


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005244voltage-gated ion channel activity
MFNASGO:0005248voltage-gated sodium channel activity
MFIDAGO:0017080sodium channel regulator activity
MFIMPGO:0017080sodium channel regulator activity
MFIBAGO:0019871sodium channel inhibitor activity
MFIBAGO:0044325ion channel binding
MFIPIGO:0044325ion channel binding
MFIDAGO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potential
MFIMPGO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potential
BPNASGO:0006814sodium ion transport
BPIEAGO:0007399nervous system development
BPISSGO:0010460positive regulation of heart rate
BPIDAGO:0010765positive regulation of sodium ion transport
BPIMPGO:0010765positive regulation of sodium ion transport
BPIEAGO:0019233sensory perception of pain
BPIDAGO:0035725sodium ion transmembrane transport
BPIDAGO:0051899membrane depolarization
BPIMPGO:0060048cardiac muscle contraction
BPIMPGO:0060371regulation of atrial cardiac muscle cell membrane depolarization
BPIMPGO:0060373regulation of ventricular cardiac muscle cell membrane depolarization
BPIMPGO:0072659protein localization to plasma membrane
BPIBAGO:0086002cardiac muscle cell action potential involved in contraction
BPIMPGO:0086002cardiac muscle cell action potential involved in contraction
BPIBAGO:0086005ventricular cardiac muscle cell action potential
BPIMPGO:0086005ventricular cardiac muscle cell action potential
BPIDAGO:0086010membrane depolarization during action potential
BPIMPGO:0086010membrane depolarization during action potential
BPIMPGO:0086012membrane depolarization during cardiac muscle cell action potential
BPIMPGO:0086014atrial cardiac muscle cell action potential
BPISSGO:0086015SA node cell action potential
BPIBAGO:0086091regulation of heart rate by cardiac conduction
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIBAGO:2000649regulation of sodium ion transmembrane transporter activity
BPIMPGO:2000649regulation of sodium ion transmembrane transporter activity
CCIBAGO:0001518voltage-gated sodium channel complex
CCIDAGO:0001518voltage-gated sodium channel complex
CCTASGO:0001518voltage-gated sodium channel complex
CCIDAGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
CCISSGO:0030018Z disc

Gene expression in normal tissue: SCN3B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCN3B


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pidp53downstreampathwayDirect p53 effectors
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCN3B

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