SCN3B
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sodium voltage-gated channel beta subunit 3 | MIM:608214 | Ensembl:ENSG00000166257 | HGNC:HGNC:20665 | PA130546912 | 11q24.1 |
GO terms in SCN3B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005244 | voltage-gated ion channel activity |
| MF | NAS | GO:0005248 | voltage-gated sodium channel activity |
| MF | IDA | GO:0017080 | sodium channel regulator activity |
| MF | IMP | GO:0017080 | sodium channel regulator activity |
| MF | IBA | GO:0019871 | sodium channel inhibitor activity |
| MF | IBA | GO:0044325 | ion channel binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IDA | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
| MF | IMP | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
| BP | NAS | GO:0006814 | sodium ion transport |
| BP | IEA | GO:0007399 | nervous system development |
| BP | ISS | GO:0010460 | positive regulation of heart rate |
| BP | IDA | GO:0010765 | positive regulation of sodium ion transport |
| BP | IMP | GO:0010765 | positive regulation of sodium ion transport |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IDA | GO:0035725 | sodium ion transmembrane transport |
| BP | IDA | GO:0051899 | membrane depolarization |
| BP | IMP | GO:0060048 | cardiac muscle contraction |
| BP | IMP | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization |
| BP | IMP | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IBA | GO:0086002 | cardiac muscle cell action potential involved in contraction |
| BP | IMP | GO:0086002 | cardiac muscle cell action potential involved in contraction |
| BP | IBA | GO:0086005 | ventricular cardiac muscle cell action potential |
| BP | IMP | GO:0086005 | ventricular cardiac muscle cell action potential |
| BP | IDA | GO:0086010 | membrane depolarization during action potential |
| BP | IMP | GO:0086010 | membrane depolarization during action potential |
| BP | IMP | GO:0086012 | membrane depolarization during cardiac muscle cell action potential |
| BP | IMP | GO:0086014 | atrial cardiac muscle cell action potential |
| BP | ISS | GO:0086015 | SA node cell action potential |
| BP | IBA | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | IMP | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | IBA | GO:2000649 | regulation of sodium ion transmembrane transporter activity |
| BP | IMP | GO:2000649 | regulation of sodium ion transmembrane transporter activity |
| CC | IBA | GO:0001518 | voltage-gated sodium channel complex |
| CC | IDA | GO:0001518 | voltage-gated sodium channel complex |
| CC | TAS | GO:0001518 | voltage-gated sodium channel complex |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0030018 | Z disc |
Gene expression in normal tissue: SCN3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCN3B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445095 | Interaction between L1 and Ankyrins |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | p53downstreampathway | Direct p53 effectors |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCN3B
CLASSFICATION
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