ASH1L
Summary: This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ASH1 like histone lysine methyltransferase | MIM:607999 | Ensembl:ENSG00000116539 | HGNC:HGNC:19088 | PA134891064 | 1q22 |
GO terms in ASH1L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IEA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0046975 | histone methyltransferase activity (H3-K36 specific) |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005694 | chromosome |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005923 | bicellular tight junction |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0002674 | negative regulation of acute inflammatory response |
| BP | TAS | GO:0006323 | DNA packaging |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0007338 | single fertilization |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IEA | GO:0032635 | interleukin-6 production |
| BP | IEA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043409 | negative regulation of MAPK cascade |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046697 | decidualization |
| BP | IEA | GO:0051568 | histone H3-K4 methylation |
| BP | IEA | GO:0061038 | uterus morphogenesis |
| BP | IDA | GO:0097676 | histone H3-K36 dimethylation |
| BP | IEA | GO:0097722 | sperm motility |
| BP | IEA | GO:1903699 | tarsal gland development |
| BP | IEA | GO:1903709 | uterine gland development |
Gene expression in normal tissue: ASH1L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ASH1L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| wikipathways | WP2369 | Histone Modifications |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD179 | Shikonin | 2 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD292 | NSC87877 | 2 |
| iGMDRD391 | OSU-03012 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ASH1L
CLASSFICATION
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